A Multiscale/Multiphysics Coupling Framework for Bioprosthetic Heart Valves (BHVs) Damage

Theoretical Biology Seminar

Meeting Details

For more information about this meeting, contact Kristin Berrigan, Jessica Conway, Carina Curto, Wenrui Hao.

Speaker: Yue Yu, Lehigh University

Abstract: Bioprosthetic heart valves (BHVs) are the most popular artificial replacements for diseased valves that mimic the structure of native valves. However, the life span of BHVs remains limited to 10-15 years, and the mechanisms that underlie BHVs failure remain poorly understood. Therefore, developing a unifying mathematical framework which captures material damage phenomena in the fluid-structure interaction environment would be extremely valuable for studying BHVs failure. Specifically, in this framework the computational domain is composed of three subregions: the fluid (blood) , the fracture structure (damaged BHVs) modeled by the recently developed nonlocal (peridynamics) theory, and the undamaged thin structure (undamaged BHVs). These three subregions are numerically coupled to each other with proper interface boundary conditions. In this talk, I will introduce two coupling problems and the corresponding numerical methods in this multiscale/multiphysics framework. In the first problem the coupling strategy for fluid and thin structure is investigated. This problem presents unique challenge due to the large deformation of BHV leaflets, which causes dramatic changes in the fluid subdomain geometry and difficulties on the traditional conforming coupling methods. To overcome the challenge, the immersogemetric method was developed where the fluid and thin structure are discretized separately and coupled through penalty forces. To ensure the capability of the developed method in modeling BHVs, we have verified and validated this method. The second part focuses on developing a fluid—peridynamics coupling framework to capture the fluid-induced material damage. In the peridynamic and other nonlocal models the loading boundary conditions should be defined in a nonlocal way, while in fluid—structure interfaces the hydrodynamic loadings from the fluid side are typically provided on a sharp co-dimension one surface. To overcome this challenge, we have proposed a new nonlocal Neumann-type boundary condition which provides an approximation of physical boundary conditions on a sharp surface. Based on this nonlocal boundary condition, we have developed a stable and asymptotically compatible fluid—peridynamics coupling framework without overlapping regions.


Room Reservation Information

Room Number: 106 McAllister

Date: 09/24/2019

Time: 1:30pm - 2:30pm