On the promise of Boolean modeling of biological regulatory networks
Speaker: Reka Albert, Dept of Physics, Penn State
Abstract: Over the past five years my group, in collaboration with wet-bench biologists, has developed and validated asynchronous Boolean models of several biological regulatory networks. I will use the modeling of within-cell signaling involved in the blood cancer T-LGL leukemia to illustrate the steps involved in Boolean modeling, the testable predictions generated by the model, and the experimental validation of these predictions. I will also discuss a few obstacles we encountered, due to the lack of timing knowledge and the large size of the state space, and the methodologies we are developing to overcome these obstacles. For example, we proposed a two-step network reduction method which was able to reduce the number of variables by 90% without affecting the system's dynamic behaviors. We also proposed an integration of Boolean rules into graph theoretical analysis, and showed that this semi-structural method can identify critical signal mediators on par with dynamic models.
Room Reservation Information
Room Number: 106 McAllister
Time: 1:00pm - 2:00pm