Dynamics of membranes and molecules at the endothelial cell surface
Speaker: Peter J. Butler, Dept of Bioengineering, Penn State
Abstract: Our group seeks to understand how cells convert force into biochemical signals. I will present evidence that the cell membrane is stressed by tension and out of plane fluctuations and that these stresses lead to perturbation of membrane microdomains. These domains may, in turn, participate in lipid and protein sorting that results in changes in biochemical signaling in the cells. Specifically, I will present results of molecular dynamics simulations of lipids and corresponding molecular scale spectroscopic measurements of lipid areal changes accompanying tension and fluctuations. In addition, I will present the first direct evidence for the participation of membrane domains in mechanosensation at the cell surface. We seek mathematical formulations that might capture these phenomenon and lead to predictive models of mechanochemical signal transduction.
Room Reservation Information
Room Number: 106 McAllister
Time: 1:00pm - 2:00pm